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In vitro, modafinil has become revealed to bind weakly but selectively to the dopamine transporter (Mignot et al 1994; Nishino et al 1998; Madras et al 2006) and, to a lesser extent, the norepinephrine transporter (Madras et al 2006). Wake-endorsing concentrations of modafinil elevated extracellular levels of monoamines, which include norepinephrin

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